Urinary Proteomics for Prediction of Preeclampsia
نویسندگان
چکیده
منابع مشابه
Urinary proteomics for prediction of preeclampsia.
Preeclampsia is a major determinant of fetal and maternal morbidity and mortality. We used a proteomic strategy to identify urinary biomarkers that predict preeclampsia before the onset of disease. We prospectively collected urine samples from women throughout pregnancy. Samples from gestational weeks 12 to 16 (n=45), 20 (n=50), and 28 (n=18) from women who subsequently had preeclampsia develop...
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PURPOSE Minimally invasive methods of predicting the risk of muscle-invasive urothelial bladder carcinoma may expedite appropriate therapy and reduce morbidity and cost. EXPERIMENTAL DESIGN Here, capillary electrophoresis coupled mass spectrometry was used to identify urinary polypeptide bladder cancer biomarkers in 127 patients. These markers were used to construct a panel discriminating mus...
متن کاملUse of 24-hour urinary protein and calcium for prediction of preeclampsia.
OBJECTIVE To assess the efficacy of 24-hour urinary protein and calcium for the prediction of preeclampsia. MATERIALS AND METHODS Two hundred normotensive women at 20-28 weeks' gestation were enrolled in the study. All women were asked to collect a 24-hour urine sample. Urinary protein and calcium were measured and expressed as milligrams per 24 hours. Sensitivity, specificity and predictive ...
متن کاملEarly Prediction of Preeclampsia
Effective screening for the development of early onset preeclampsia (PE) can be provided in the first-trimester of pregnancy. Screening by a combination of maternal risk factors, uterine artery Doppler, mean arterial pressure, maternal serum pregnancy-associated plasma protein-A, and placental growth factor can identify about 95% of cases of early onset PE for a false-positive rate of 10%.
متن کاملThe prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
BACKGROUND Late-onset preeclampsia is the most prevalent phenotype of this syndrome; nevertheless, only a few biomarkers for its early diagnosis have been reported. We sought to correct this deficiency using a high through-put proteomic platform. METHODS A case-control longitudinal study was conducted, including 90 patients with normal pregnancies and 76 patients with late-onset preeclampsia ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.110.164285